Triglyceride regulate ACE2 level through MTHFD1
نویسندگان
چکیده
منابع مشابه
Chronic ANG II infusion increases plasma triglyceride level by stimulating hepatic triglyceride production in rats.
We recently observed that ANG II receptor blocker therapy improved the overproduction of triglyceride (TG) in fructose-fed rats and Zucker fatty rats with insulin resistance, which in turn suggests that ANG II may stimulate TG production. Accordingly, we investigated the effects of ANG II on TG production and the association with insulin resistance in normal rats. Male Wistar rats were continuo...
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DNA methylation is an epigenetic mechanism that has important functions in transcriptional silencing and is associated with repressive histone methylation (H3K9me). To further investigate silencing mechanisms, we screened a mutagenized Arabidopsis thaliana population for expression of SDCpro-GFP, redundantly controlled by DNA methyltransferases DRM2 and CMT3. Here, we identify the hypomorphic m...
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OBJECTIVE Elevated plasma triglycerides (TGs) have been included in diabetes risk prediction models. This study examined whether elevated TGs predict risk for impaired fasting glucose (IFG). RESEARCH DESIGN AND METHODS This study used the baseline and longitudinal follow-up data from the Multi-Ethnic Study of Atherosclerosis (MESA). The analysis included non-Hispanic whites, African Americans...
متن کاملSevere combined immunodeficiency resulting from mutations in MTHFD1.
Folate and vitamin B(12) metabolism are essential for de novo purine synthesis, and several defects in these pathways have been associated with immunodeficiency. Here we describe the occurrence of severe combined immunodeficiency (SCID) with megaloblastic anemia, leukopenia, atypical hemolytic uremic syndrome, and neurologic abnormalities in which hydroxocobalamin and folate therapy provided pa...
متن کاملLower serum triglyceride level is associated with increased stroke severity.
BACKGROUND AND PURPOSE A previous study showed that low triglyceride concentration predicts higher mortality after stroke. The aim of our study was to determine whether serum triglyceride level is associated with stroke severity on admission. METHODS 863 consecutive patients with acute ischemic stroke were included. Serum triglyceride level was measured within 36 hours after stroke onset. Str...
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ژورنال
عنوان ژورنال: Journal of Biosciences
سال: 2021
ISSN: 0250-5991,0973-7138
DOI: 10.1007/s12038-021-00178-y